A REVIEW ON THERAPEUTIC POTENTIAL OF TOLL-LIKE RECEPTORS IN CARDIOVASCULAR DISEASES

Jumana K. K.*, Sajeena C. H., Shijikumar P. S., Sirajudheen M. K. and Sherin A.

ABSTRACT

Toll-like receptors are the surface molecule and they are most responsile for the recognition of the exogenous infectious ligand and endogenous molecule, which are released during host tissue injury and there by downstream signelling pathway are activated by the interaction of TLRs with their ligand. That induces an immune responses by producing cytokines, type 1 interferones and other inflammatory diseases including atherosclerosis, septic cardiomyopathy, viral myocarditis, ischemia and cardic remodeling after myocardial infraction. Individual TLRs are also initiate and integrate homeostasis response within heart. Blockade of these TLRs may be beneficial in both preventing and decreasing the complications in cardiovascular system. The proposed review on role of toll like receptors in cardiovascular diseases reveals that endogeneous molecule which trigger innate immunity via TLRs in cardiovascular diseases.

Keywords: Atherosclerosis; Receptors; Infection/Inflammation; Arteries; Immunology.