SYSTEMATIC REVIEW ON APPLICATION OF NANOTECHNOLOGY IN WOUND HEALING AND ULCER

Fasna Fabin P. K.*, Nasiya N., Jerrin Jose K., Dr. Shijikumar P. S., Dr. Sirajudheen M. K. and Sherin A.

ABSTRACT

Wound healing and ulcer is a complex process and has been subjected of any intense research for a longtime. Its management have more socio economic impact on clinical practices. Most skin lesion are called wound and primarily are divided into chronic and acute. Ulcer presently called as chronic wound. Nanotechnology is the study of extremely small structure having size of 0.1 to100nm.Nanomedicineis relatively new yield of science and technology. Biomaterials arises through nanotechnology have dramatically expanded the range of tools used for injection control and accelerate wound healing. Nano materials that including polymeric metallic and ceramic based nanomaterial that could used as therapeutic delivery agent to accelerate regeneration of damaged dermal and epidermal tissue. Nano engineered biomaterials have tremendously improve the range of tools utilized for control of as well as acceleration of healing of diabetic foot ulcer, Over the few decades potential nonomaterial like polymeric and metallic nanoparticle and electro spasm nanofibers for DFU treatment. Nanoparticle incopraed hydro gel or amoxicillin for eradiation of H.pylori. This review based on the different methods and type of nanoparticle in the most recent development in wound healing and ulcer diagnosis including silver oxide nanoparticle alleviated indomethacin, nanoparticle incorporated hydrogel, tripolyphosphate nanoparticle. Apart from this reviw focused on the nanoparticle enhance effect of stimulate cell proliferation and shorter the wound healing time.

Keywords: Gene therapy, growth factor, nbacterial infection, biomaterial, hyaluronic acid, inflammation process, wound healing, ulcer, silver, gold, nanoparticle, nanotechnology.