A GUIDE TO SOLID LIPID NANOPARTICLES

Komal Sanjay Mande*, Anuja Vilas Barve, Vijay R. Mahajan and Amol S. Deshmukh

ABSTRACT

Solid lipid nanoparticle (SLN) are proposed as a replacement sort of colloidal drug carrier system. It consists of spherical solid lipid particles within the nanometer ranges, which are dispersed in water or in aqueous surfactant solution. Solid lipid nanoparticle technology represents a promising new approach to deliver hydrophilic also as lipophilic drugs. Thanks to their unique size dependent property, lipid nanoparticles offer to develop the new therapeutics. Scaling from the assembly process from lab scale to industrial scale are often easily achieved. This review focuses on the utility of solid lipid nanoparticles in terms of their advantages, production methodology, characterization and applications. Solid lipid nanoparticles hold a novel platform for reaching the goal of controlled and targeted drug delivery and subsequently pulled wide attention of researchers in the field of nanotechnology.

Keywords: Solid lipid nanoparticles, Colloidal system, Drug release, Homogenization, Particle size.