CINNAMALDEHYDE ANALOGUES: A NOVEL THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS

Aysha K. M.*, Thasneem C. K., Dr. Shijikumar P. S., Dr. Sirajudheen M. K. and Sherin A.

ABSTRACT

Cinnamaldehyde analogues are a class of chemical substances originated from derivatives of cinnamaldehyde, and are structurally characterized by the presence of cinnamoyl moiety. Cinnamaldehyde is obtained from cinnamon which consists of dried inner bark of the shoots of coppiced trees of cinnamomum zeylanicum of the family Lauraceae. They have diverse range of biological property such as flavourant, agrichemical, anti-microbial agent, anticancer agent, mild astringent, fungicide, anti- inflammatory etc. Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of joints which also cause inflammation of tissues around the joints as well as in the other organs in the body, which is responsible for the deformity and disability. Due to the presence of highly reactive α, α-unsaturated carbonyl pharmacophore in their structure, these molecules are apt to react with some enzymes and receptors as electrophiles. The naturally occurring molecules of this group such as transcinnamaldehyde and all have attracted lots of interest for their bioactivities especially for anti-inflammatory properties. This review summarises the progress of cinnamaldehyde analogue on anti-arthritic patients, illustrate its potent bioactivity, and discuss their potential as therapeutic agents.

Keywords: Cinnamaldehyde, Schiffs base, Phenylpropanoids, Anti-inflammatory, Rheumatoid Arthritis.