EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

EFFICACY AND SAFETY OF VARIOUS DOSES OF RITUXIMAB IN RHEUMATOID ARTHRITIS (RA) PATIENTS: A SYSTEMATIC APPROACH TO RANDOMIZED CLINICAL TRIALS

Sanjo Saijan, Joicy Jose*, Aby Paul, Swetha Jos and Jobin Kunjumon Vilapurathu

ABSTRACT

Rituximab being a cytolytic monoclonal antibody is used to various disease including Non- Hodgkin’s Lymphoma, Chronic lymphocytic Leukemia, Wegener’s granulomatosis, microscopic polyangiitis and in combination with methotrexate for rheumatoid arthritis who failed TNF antagonist therapy.[1] Based on the clinical evidence the dose of Rituximab for Rheumatoid arthritis varies. The dose which shows the maximum efficacy in RA is still a challenging task for the physicians. This is a narrative review which emphasis on the efficacy and safety of various doses of Rituximab in RA patients.

Keywords: Chronic lymphocytic Leukemia, Wegener’s granulomatosis.


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SJIF Impact Factor: 7.065

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