CORRELATION OF BRUSH CYTOLOGY AND IMPRINT CYTOLOGY WITH HISTOPATHOLOGY IN UPPER GASTROINTESTINAL LESIONS

Dr. Prachi Singh, Dr. Faiyaz Ahmad*, Dr. Shyamoli Dutta, Dr. Seema Awasthi and Dr. V. K. Singh

ABSTRACT

Background: Various pathologies can affect upper gastro intestinal tract. Malignancies are not uncommon and early diagnosis have excellent outcomes. Endoscopic brush cytology has sensitivity and specificity between 90%-96%. Imprint cytology is a rapid tool with sensitivity and specificity about 95%-100%. Histopathology is gold standard, but is time consuming compared to cytology. Objectives: Correlation of brush cytology, imprint cytology and standard histopathology of upper gastrointestinal tract lesions. Material and methods: 50 patientswith upper gastrointestinal tract lesions were included. cytological brushingdone from lesions. Biopsies were taken and the imprint smears were then made. Diagnoses were made on brush smears, imprint smears and histopathological sections separately. Results: Patients were between 20-85 years. Lesions of esophagus sampled (44.0%), gastric (40.0%) and duodenum (16.0%). Conclusions: Our study concludes that cyto-morphology can play a prominent diagnostic and prognostic role in evaluating digestive tract cancers. Touch smear cytology is efficient and reliable for immediate detection of upper gastrointestinal diseases.

Keywords: Histopathology, imprint cytology, brush cytology.