MICRONEEDLE BASED DRUG DELIVERY DEVICE

*Nejiya Nasrin, Thasneem C. K., Dr. Shijikumar P. S. and Dr. Sirajudheen M. K.

ABSTRACT

The main objective of the review is to update the microneedles for the supply of medicines and vaccines. Applicators of therapeutically active drugs cannot cross the stratum corneum effectively. Microneedle patches have been developed to penetrate the stratum corneum with micro scale pores that are large enough to allow medications. The microneedles are manufactured using a microelecromechanical system that uses silicon, metals, polymers or polysaccharides. Five main type of microneedle design have been described, namely solid, coated, solvent, hollow and hydrogel forming microneedles. Microneedles can be used to administer macromolecules such as insulin, growth hormones, immunobiological proteins and peptides. Microneedles containing cosmeceuticals are currently available to treat acne, pigmentation, scars, wrinkles and to improve skin tone. Microneedle technology is capable of dosing very precisely, complex release patterns, local administration and improvement of the biological stability of the drug by storing in a micro volume that can be precisely controlled. The proposed revision of the microneedle for the supply of drug and vaccines revealed that it improves the dosage and the supply of micro volume of medicines and has made more progress in cilinical practice to allow better pharmaceutical therapies, vaccination and other application.

Keywords: Microneedles, Transdermal drug delivery, materials, fabrication methods.