ANTIDEPRESSANT-LIKE EFFET OF HYDRO ALCOHOL EXTRACT OF STEM BARK FROM XYLOPIA VILLOSA IN MICE

Bakou Niangoran François*, B. A. Abdoulaye, Diabate D. and Atayi E.

ABSTRACT

Objective: The aim of the present study is to evaluate the antidepressant-like effect of hydro alcoholic extract of stem bark of Xylopia villosa. in mice. Material and Methods: Mice were randomly divided into five groups (n = 5/group): control group (distilled water), standard group where Amitriptyline (20mg/kg b.w., IP) was used as standard drug and three test groups where three doses of the hydro alcohol extract of XV (50, 100, and 200 mg/kg) was used for two weeks treatment. To assess the antidepressant-like effect of XV forced swimming test (FST), tail suspension test (TST) and measurement of locomotor activity test (OFT) have been done in mice. Results: The results showed that a strong and dose-dependent antidepressant effects in different mice models. The main findings of the XV significantly reduced the duration of immobility times in the forced swimming test (p < 0.001). Likewise, the extract significantly decreased the immobility time in the tail suspension test (p < 0.001). Conclusion: The results of the present work suggest that a hydro alcohol extract of stem bark of Xylopia villosa may possess an antidepressant effect.

Keywords: Xylopia villosa., antidepressant, activity, mice.