STUDY OF SERUM MAGNESIUM LEVELS AND ITS CORRELATION WITH IMPORTANT NUTRIENTS

Dr. Md. Abdul Kader Zilani*, Dr. Jannatul Ferdous, Dr. Md. Salahuddin Shah, Dr. Mohammad Nurul Islam Khan, Dr. Md. Rafiquzzaman Khan and Dr. Priobrata Karmakar

ABSTRACT

Background: Magnesium (Mg) is essential to the basic nucleic acid chemistry of life and thus is essential to all known living organisms. Mg is important for maintaining of DNA. Magnesium is extremely necessary for proper ATP synthesis (Buchachenkoa et al. 2009). Magnesium (Mg2) is the second most abundant intracellular cation after potassium and the fourth most abundant cation of the body after calcium, potassium, and sodium. Mg2 is involved in hundreds of enzymatic reactions and is essential for life. Mg2 is an important co-factor for many biologic processes, most of which use ATP. Mg2 is an essential mineral that is important for bone mineralization, muscular relaxation, neurotransmission, and other cell functions (Rude et al. 2000). Extracellular Mg2 concentration is tightly regulated by the extent of intestinal absorption and renal excretion. Objective: In this study our main goal is to measure serum magnesium levels and its correlation with important nutrients. Method: This Observational cross-sectional study was done at Department of Haematology, BSMMU, Dhaka from September 2016 to August 2017. During the study period of total 85 patients were enrolled for the study. Result: Investigation of the population, it was that mean serum sodium was 136.00±4.54 mmol/L, serum potassium was 3.77±0.49 mmol/L, serum chloride was 101.85±11.05 mmol/L, serum magnesium was 1.80±0.54 mg/dL, serum albumin was 34.56±6.47 g/L, serum calcium was 1.80±0.54 mg/dL, serum creatinine was 0.78±0.18 mg/dl, RBS was 5.98±1.22 mmol/l. Positive correlation (r= 0.15; p=0.16) between serum chloride (g/l) and magnesium (mg/dl) but not statistically significant. Positive correlation (r= 0.04; p=0.67) between serum potassium (mmol/l) and magnesium (mg/dl) but not statistically significant. Positive correlation (r= 0.05; p=0.62) between serum magnesium (mg/dl) level with serum sodium (mmol/L) level but not statistically significant. Positive correlation (r= 0.451; p=<0.001) between serum magnesium (mg/dl) level with serum calcium (mg/dl) level that was statistically significant. Mean serum magnesium was found 1.56±0.60 mg/dl in ALL patients and 1.89±0.49 mg/dl in AML patients which was significantly lower in ALL patient than AML patients (p =0.009). serum magnesium level majority 44(51.8%) was found hypomagnesaemia followed by 38(44.7%) were normal magnesium and 03(3.5%) were hypermagnesaemia. Conclusion: From our result we can conclude that, there were no significant differences in the incidence of serum Sodium, Potassium and Chloride between patients with AML and ALL, which was more frequently observed in AML patients.

Keywords: Acute leukemia, hypocalcemia, serum magnesium, hypomagnesaemia.