FORMULATION AND EVALUATION OF IPN MICROSPHERE OF INDOMETHACIN

Jyoti More*, Archana Barhate, Sagar D. Shinde, Swati B. Kavade and Pradnya Salunkhe

ABSTRACT

Interpenetrating polymer network (IPN) is one of the valuable novel biomaterials. An IPN is a combination of at least two polymers and IPN can produce synergistic effect by sharing the properties of both the polymer. IPN microspheres of Indomethacin were prepared using emulsion cross-linking method. IPN Microspheres were prepared using sodium alginate and polyvinyl alcohol (PVA) in the ratio of 1:2, 1:3 and 1:4 using glutaraldehyde as a cross linking agent. Compatibility studies suggested no physicochemical interaction between the drug and the polymers. Microspheres were evaluated for particle size, entrapment efficiency, percentage yield, and equilibrium water up take. By increasing the ratio of poly vinyl alcohol, a slight increase in percent entrapment efficiency was observed. The effect of cross-linking on percent entrapment efficiency was significant. Increase in the amount of cross-linker in the matrices; significantly decrease the percent equilibrium water uptake. In-vitro dissolution study showed 90-98 % drug release at the end of 24 h.

Keywords: Indomethacin, interpenetrating polymer network, sodium alginate, polyvinyl alcohol.