LIQUISOLID COMPACTION TECHNIQUE FOR ENHANCING SOLUBILTY AND IMPROVEMENT OF DISSOLUTION

Chaursiya Ajay C.*, Patel Jignesh S., Dumpala Rajesh L.

ABSTRACT

Oral route of administration has been one of the most appropriate and broadly recognized route of delivery for most of therapeutics, because of its benefits such as easily administrable, improved patient compliance and convenience. Many drugs having poor water solubility is restricted by the dissolution rates which depends on the surface area available for dissolution. Enhancement of bioavailability of drugs having poor water solubility is the most challenging aspects for drug development. A more recent technique “Liquisolid compaction technique” has been used to formulate water insoluble medications into solid release forms. It is an innovative and capable practice to overcome this concern and it is based on mixture of insoluble drug in non-volatile solvent and combination of drug loaded solution with suitable carrier and coating substance. The usage of non-volatile solvents improves wettability and assures molecular dispersal of drug in preparation and finally points to increased solubility. Surface area of drug increased with that increased bioavailability and increased aqueous solubility of drug is observed

Keywords: Poorly water solubility, non-volatile, carrier, coating substance, liquisolid compacts.