FORMULATION AND EVALUATION OF ONDANSETRON HCL ORALLY DISINTEGRATING TABLETS

Vijay Kumar Sharma*, Dr. Shameem Ahmad, Dr. Nasiruddin Ahmad Farooqui and Mohd. Mujahid

ABSTRACT

Oral medication conveyance is the most prominent defeat. It is outstanding since quite a while for its generally utilized course of organization among all the failure that has been investigated for the precise conveyance of medication arranged different measurements from the pharmaceutical items. Dysphagia is a typical issue which needs to look in all times of gatherings in worry to strong dose shapes. The patient needs to improve consistency to take care of the problem of Dysphagia. The tablet which has the ability to dissolve into mouth has risen as an option in contrast to regular oral medication use. Based on present work, Oro-dispersible tablets of Ondansetron were structured to expand technique, crospovidone and Croscarmellose sodium in the blend since super disintegrates were utilized alongside straightforwardly miniaturized microcrystalline cellulose to improve mouth feel. The tablets for clumps arranged were assessed for stiffness, friability, sedate substance, consistency, wetting time and water assimilation proportion and in vitro dissolution time. In light of in vitro scattering time (Approximately 7-30s), All detailing were tried for in vitro medication release time (in phosphate buffer). Check the momentary security (for three months at 400 C ±2 /75% ±5%RH), and medication excipients connection contemplate. Among all the definition, the definition arranged by Croscarmellose was found to have the least scattering time 7.36s. Momentary dependability examines the best detailing showed that not too much change was there in medication data and in vitro scattering time of span.

Keywords: Crospovidone; Croscarmellose sodium; Ondansetron hydrochloride; Oro dispersible tablets.