FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF AN ANTI DIABETIC DRUG

Medisetty Gayatri Devi, Lakshmi Usha Ayalasomayajula*, Radha Rani Earle and Dr. P. Uma Devi

ABSTRACT

Diabetes Mellitus is a result of reduced insulin secretion from pancreas, and insulin action in the body or both. They are several natural as well as synthetic drugs like insulin, biguanides, sulphonylureas, thiazolidinodiones, meglitinides etc. for the treatment of diabetes. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances incretin hormone activity, sustains insulin levels, and reduces glycemia in Type II diabetes mellitus. Therefore it is an anti-diadetic drug used in the treatment of Type II diabetes mellitus and has been selected to prepare sustained release dosage forms. In present investigation an attempt has been made to design and develop Vildagliptin sustained release matrix tablets using Xanthan gum, Guar gum and their combination as release retarding polymers by direct compression method. Xanthan gum, Guar gum and their combination are used in various concentrations in the preparation of tablets. Hence sustained-release tablets were evaluated for various physical parameters namely– Hardness, Weight variation, Friability, Drug Content uniformity test etc. Drug release studies were also carried out in pH 6.8 phosphate buffer. By evaluating all the physical parameters and drug release studies F11 containing a mixture of Xanthan gum and Guar gum as release retarding polymer was optimized as the best formulation.

Keywords: Diabetes Mellitus, Sustained release matrix tablets, Direct compression method, Xanthan gum, Guar gum.