COMPARISON BETWEEN PROPOFOL AND DEXMEDETOMIDINE AS AN AGENT OF CONSCIOUS SEDATION IN PATIENTS UNDERGOING TYMPANOPLASTY: A RANDOMISED CONTROLLED TRIAL

Md. Abdur Rahim*, AKM Akhtaruzzaman, Mir Mohammad Rifat Chowdhury, Md. Arif Uddin, Iqbal Hossain Chowdhury, S. M. Rashidul Hasan

ABSTRACT

Objective: In this study our main goal is to Evaluation of conscious sedation in patient undergoing tympanoplasty by intravenous propofol and intravenous dexmedetomidine. Method: This Randomised prospective clinical trial study was carried out with the patients who underwent tympanoplasty conducted at ENT operation theatre in BSMMU, Dhaka according to inclusion & exclusion criteria from February 2016 to February 2018. ASA I-II patients aged (18-45) years undergoing tympanoplasty were enrolled. Patients were randomized as Group I and Group II by computer-gerenated randomization where there was 30 patients in each group (n=30). Results: During the study, a computer-generated randomization table was used to allocate the patients into 2 equal groups, 30 in each where Group I received dexmedetomidine and Group II received propofol. Observations were made during perioperative period for conscious sedation effectiveness on haemodynamics SBP, MAP,DBP,HR,SpO2 on different time intervals, surgical field bleeding status, patient satisfaction, surgeon satisfaction, intraoperative rescue sedation, intraoperative rescue analgesics, postoperative rescue analgesics, time to achieve target Ramsay sedation scale (RSS) after induction, intra and postoperative pain intensity level, and adverse effects. Conclusion: From our results we can conclude that, dexmedetomidine with local anaesthetic lignocaine infiltration provides better outcome of conscious sedation in terms of patients satisfaction, surgeons satisfaction, reduce per operative surgical site bleeding for patients undergoing tympanoplasty.

Keywords: Propofol, Dexmedetomidine, haemodynamics. Tympanoplasty.