SOLUBILITY ENHANCEMENT OF NEPAFENAC USING DIFFERENT SOLUBILIZERS

Deepak G. Wagh*, Dr. S. R. Shahi, Suresh Bora, Priyanka D. Dabir, Swati Deore and Datta Magar

ABSTRACT

Aim of the present work is to investigate the effect of Sulfo butyl ether-β-cyclodextrin (SBE-β-CD) and different solubilizers on the solubility of Nepafenac. Apart from SBE-β-CD the three different solubilizers were used for the purpose, Polyethylene glycol 400 (PEG 400), Cremophor RH and Polysorbate 80. By physical observation it was observed that the solubility of Nepafenac was increased significantly with SBE-β-CD and the effect of different concentration of SBE-β-CD on the solubility of the drug was studied which was further investigated and confirmed by phase solubility study with the help of UV spectroscopy. From the phase solubility diagram, the increase in solubility of Nepafenac with 1 M, 1.5M, 2 M, 3 M was found to be 2.38 times, 2.725 times, 4.401 times and 5.857 times respectively. The drug solubility was increased linearly up to 3 M of SBE-β-CD. From the above result, the optimum concentration of SBE-β-CD was selected i.e. 3M and it was concluded that SBE-β-CD is the best solubilizer among all selected.

Keywords: Solubility, Nepafenac, Solubilizer, Sulpho butyl ether-?-Cyclodextrin.