LYOPHILIZATION: PROCESS, METHODS AND APPLICATION

Gadre Harish*, Borse Tushar, Ola Monika and Bhaskar Rajveer

ABSTRACT

Lyophilazation is the common, but cost-intensive process. Freezing is an equally important step in Lyophilization, as it affects both process efficiency and quality of the product. However simple concept, freezing is probably the most complex step in lyophilisation. Therefore, to get a more comprehensive understanding, the lyophilzation methods and application are first summarized. The different techniques or method that can be used in lyophilisation are also reviewed. The purpose of this review is to make the reader aware not only of the significance but also of the complexities of the freeze stage in lyophilisation. In this review article there are many method introduced with different method of lyophilisation and used of lyophilzation production in different area.

Keywords: Theory of Lyophilization, Principle, The process steps, Traditional Lyophilization technology, Different Methods of Lyophilization, Applications.