CLINICOPATHOLOGICAL SPECTRUM OF PRENEOPLASTIC AND NEOPLASTIC CERVICAL LESIONS IN A TERTIARY CARE CENTER

Anurita Saigal*, Anchana Gulati, Rajni Kaushik and Rajeev Sood

ABSTRACT

Background: Cervical cancer is one of the most frequent cancer affecting women worldwide. Developing countries account for 80% cases. In India, it is the 2nd leading cause of female cancer. Persistent infections and preneoplastic lesions establish over a period of 5-10 years and set the soil for neoplastic transformation. Spectrum of lesions can differ in various parts of the country. Hence we planned to study the frequency and clinicopathological spectrum of preneoplastic and neoplastic lesions of the cervix in our region. Materials and Methods: This cross sectional, observational study was carried out between July 2017 and June 2018 for a period of one year in the Department of Pathology, Indira Gandhi Medical College, Shimla.Ninety three patients diagnosed with preneoplastic and neoplastic cervical lesions were included in the study.The frequency and morphological spectrum of these lesions was evaluated. Results: Majority of the samples were cervical biopsies (81.72%). Age range of patients was 27-85 years (mean age 54.5 years) Maximum number of cases of both preneoplastic and neoplastic lesions were in the age group 41-50 years. Neoplastic lesions comprised 81.72% and preneoplastic lesions 18.28% of the total cases. Preneoplastic lesions included CIN I (58.82%), CIN III (23.53%) and CIN II (17.65%) in order of frequency .Majority of the neoplastic lesions were Squamous cell carcinoma. Most common subtype of Squamous cell carcinoma was Non keratinizing squamous cell carcinoma. Conclusion: This study can be taken as a small step providing the frequency, clinical presentation and histopathological spectrum of preneoplastic and neoplastic cervical lesions in our hill state. Emphasis is required on adequate cervical screening procedure with follow up cervical biopsies to help in early diagnosis and management of these lesions.

Keywords: Cervical cancer, preneoplastic, neoplastic.