ESTIMATION OF SERUM 25- HYDROXY VITAMIN D AND ZINC IN PATIENTS OF DIABETES MELLITUS TYPE 2.

Dr. Garima Sehgal*, Dr. Tejinder Singh and Jaswant Kaur

ABSTRACT

Diabetes mellitus is chronic disease characterized by defective insulin production or utilization. Type-2 diabetes mellitus has mainly peripheral insulin resistance as a cause with or without insulin secretary defects. Vitamin D plays a role in calcium metabolism. Vitamin D deficiency may be associated with a range of diseases, including cardiovascular disease and type 2 diabetes and has been associated with impaired insulin action, through direct effect of vitamin D on the β-cell function. In particular, type-2 diabetes mellitus has been shown to be associated with abnormalities in the metabolism of Zinc, Chromium, Magnesium and Manganese. The serum levels of Zinc and Magnesium are usually low in diabetic patients. Aim: To evaluate serum 25 –Hydroxy vitamin D and serum zinc levels in type 2 diabetes mellitus patients. Material and Methods: This hospital-based study was conducted on 45 diagnosed type 2 Diabetes mellitus patients and 25 non-diabetic age and gender matched controls. Blood sample was collected in plain vial and serum 25-hydroxy vitamin D levels were evaluated by ELISA technique and serum zinc were estimated calorimetrically. Results: The Mean values of serum 25-hydroxyvitamin D levels in study group and control group were 16.31± 14.03 and 26.63 ± 16.54 respectively. The decrease in Vitamin D levels in study group as compared to control group shows statistically significant association (p value < 0.07). The Mean values of serum Zinc levels in study group is 61.9± 11.6 and control group is 96.4 ± 8.10 respectively. The decrease in serum Zinc level in study group as compared to control group show statistically significant association (p value of <0.01). Conclusions: In this study we observed significant decrease of serum 25-hydroxy vitamin D and serum zinc in type 2 diabetes mellitus patients.

Keywords: Type 2 Diabetes Mellitus, 25-Hydroxy Vitamin D, and Serum Zinc.