COMPARISON OF SALIVARY BETA GLUCURONIDASE ACTIVITY IN CHRONIC PERIODONTITIS WITH OR WITHOUT DIABETES MELLITUS

Amee Poshiya*, Palak Kothia, Rima Pareshkumar Gandhi and Margi Shingala

ABSTRACT

Introduction: Various studies have been done to diagnose Periodontitis with the use of salivary analysis. The advantage of the method is that saliva is easily available. There are various markers of the periodontal diseases that are found in the fluid of saliva. Hence the present study was done to estimate the salivary beta Glucuronidase activity in patients diagnosed with chronic Periodontitis with and without diabetes mellitus. Materials & Methods: A total of 160 patients with age range of 30 to 70 years were included in the study. Both male and females were included. For saliva parameter estimation, 50 uml of saliva was collected in the standard and properly designated tubes. For the control the unionized distilled water was used. Results: There were 90 females and 70 males. When comparing the mean BG activity values between the groups, the mean BGA levels of Group IV (1.64 ± 0.39) was significantly higher than mean BGA levels of Group I, II, III. The P-value was < 0.05. The mean BGA levels of Group III (0.84 ± 0.30) was significantly higher than mean BGA levels of Group I, Group II at 5 % level. The p-value was < 0.05. Discussion & Conclusion: It is considered that salivary beta Glucuronidase is a potential biochemical marker of the tissue destruction. A positive correlation was found between the clinical periodontal diseases parameters and salivary beta Glucuronidase. There were increases in salivary beta Glucuronidase level in diabetic patients with periodontal diseases as compared to non diabetic patients with periodontal diseases.

Keywords: Beta Glucuronidase, diabetes, periodontal diseases.