ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF CO(II), NI(II) AND ZN(II) COMPLEXES OF 6-PYRIDYL-5,6-DIHYDROBENZO[4,5]-IMIDAO[1,2-C] QUINAZOLINE (N-N)

Chaithra K.*, H. G. Bheemanna and V. Gayathri

ABSTRACT

Cobalt(II), Nickel(II), and Zinc(II) salts react with a bidentate N-heterocycle, 6-pyridyl-5,6-dihydrobenzo[4,5]- imidao[1,2-C] quinazoline (N-N) to yield complexes of the composition MX2(N-N). nH2O (n = 0, M = Co, X = I or ClO4; n =1, X = Cl or Br; n = 0, M = Ni, X = Br; n = 0, X = Cl or ClO4; n = 0, M = Zn, X = Cl) and [{Zn (OClO3)(N-N)1.5}ClO4]2. The complexes are insoluble in common organic solvents but are soluble in dimethylformamide in which they behave as non-electrolytes excepting the chloro, bromo complexes of cobalt and the complex [{Zn(OClO3)(N-N)1.5}ClO4]2 which behave as uni-univalent electrolytes. The antimicrobial activity has been carried out using gram positive and gram-negative bacteria like Staphylococcus Aureus, Pseudomonas species, Bacillus species, E-Coli, Klebsiella at different concentration by Agar diffusion method and some fungus species like Aspergillus, Penicillium, Candida have been tested. The results are compared with the standard drug Amoxicillin 500 mg. The activity index was recorded using zone of inhibition.

Keywords: Cobalt, nickel, zinc, quinazoline complexes, N-heterocycle, antimicrobial, antifungal, Agar diffusion.