1.0 THE AMELIORATIVE EFFECTS OF SOLANUM MELONGENA (GARDEN EGG), SOLANUM LYCOPERSICUM (TOMATOES) AND DAUCUS CARROT SUB.SATIVUS EXTRACTS ON LIPID PROFILE AGAINST LEAD INDUCED TOXICITY IN WISTAR RATS.

Dennis Amaechi*, Etu A. Felix, Ekpe I. P., G. E Udosen and Yisa B. N.

ABSTRACT

Lead effects were assessed by analyzing the impacts of the extract on the lipid profile of rats. Thirty five male wistar rats weighing 85-110g were distributed into five groups consisting of seven rats each. Group I served as control group, group II served as the test group, being given the experimental lead acetate, groups III, IV and V served as treatment groups being given carrot and garden egg, carrot and tomato and carrot, tomato and garden egg respectively.Extraction and all biochemical analysis were carried out using standard laboratory techniques. Lead acetate was induced in the rats orally at a dose of 50mg/kg weight and 200mg/kg of the fruit extracts of 14 days. On the 15th day, the animals were sacrificed and the blood was collected via cardiac puncture and used for analysis using a spectrophotometer. LDL concentration in group 2 is significantly higher (p˂0.05) in comparison with the level of group 1. There is a non-significant decrease in group 5 (p˂0.05) compared to the with the LDL concentration level of group 1. TAG concentration in group 2 is significantly lower (p˂0.05) compared to the concentration level of group 1. There is a significant decrease in group 5 (p˂0.05) compared to the TAG level of group 1. Total cholesterol concentration in group 2 is non-significantly lower (p˂0.05) in comparison with the concentration levels in group 2. HDL concentration level in group 2 significantly increased (p˂0.05) compared to the concentration in group 1. Concentration of HDL in group 5 increased significantly (p˂0.05) in comparison with group 1. Results suggest lead exposed Wister rats having altered lipid profile are at high risk of cardiovascular diseases. However, the lead toxicity can be treated with the juicy extracts of garden egg, tomato and carrot.

Keywords: Lipid profile, toxicity, cardiovascular diseases,cholesterol and extraction.