ACUTE TOXICITY STUDY OF TOTAL ALKALOID OF MITRAGYNA CILIATA (RUBIACEAE) IN FEMALE RATS

Dr. Yemié Aby Alain*, Oungbé Monkoué Désiré, Konan Armand Marcelin, N'guessan Jean-David

ABSTRACT

Mitragyna ciliata (MYTA) is a plant species whose stem barks are traditionally used in the treatment of malaria. The toxicity of total alkaloids extracted from this plant was studied in female rats. The extract was administered orally in single doses of 2000 mg / kg and 5000 mg / kg bw. The animals were observed continuously for 24 h and daily for 14 days. During this period, the clinical signs were recorded, and the body weight of the animals noted once a week. The blood of the rats was also drawn weekly for the determination of the biochemical and hematological parameters. The results obtained revealed an absence of toxic effect of the alkaloids of this plant, with a lethal dose 50 (LD50) greater than 5000 mg / kg bw. It emerges from these results that the total alkaloids of MYTA are therefore classified in category 5 of the globally harmonized classification system for chemical substances, a category characterizing substances of low toxicity.

Keywords: acute toxicity, total alkaloid, Mitragyna ciliata, clinical signs.