PREPARATION & EVALUATION OF VALSARTAN NANOPARTICLES

Chirravuri S. Phani Kumar*, V. Jyothi Krishna Reddy, V. Srinivasa Rao, K. Suresh Kumar, N. V. N. Koteswara Rao, Surisetti Roja

ABSTRACT

Valsartan belongs to BCS class II drugs (low aqueous solubility and high permeability), hence the oral absorption (20-30%) of the drug is dissolution rate limited. Improvement of dissolution velocity of Valsartan is desired so as to improve its bioavailability. The objective of the present research is to improve the dissolution rate of the drug adopting the concept of nanonization. Simple mixing and probe sonication were employed to prepare nanocrystals using 3 polymers namely Polyvinyl pyrrolidone (PVP K30), polyvinyl alcohol (PVA), polyethylene glycol (PEG 400) as stabilizers. Nanoparticles were characterized by FT-IR, SEM, assay, dissolution & micromeritics studies. Finally simple mixing was considered as best method compared to probe sonication method, in which PEG 400 is the best polymer as stabilizer to enhance the dissolution of Valsartan at 1 : 0.5 (Valsartan: PEG 400) concentration ratio.

Keywords: Valsartan, nanoparticles, simple mixing, probe sonication.