VARIATIONS IN LIVER BIOCHEMICAL TESTS IN PATIENTS WITH CHRONIC HCV AND HEPATITIS B IN LIBYA

Jbireal J. M., Altayeb Elazomi*, Kamal E. Alshebani, Fawzia Shawesh and Abdurraouf Zaet

ABSTRACT

Chronic hepatitis is not a single disease, but rather a complex clinico-pathological syndrome with multiple causes, varying stages of necro-inflammatory and sclerosing liver damage, different prognoses and responses to treatment. This research was a comparative case control study. It implicated about 120 blood samples from patients with chronic viral hepatitis, where 60 with HCV and 60 with HBV infection. The results of this study showed a highly significant difference regarding liver biochemical tests. The mean concentration of Total Bilirubin, Direct Bilirubin, Indirect Bilirubin and ALT enzyme in HCV and HBV patients (0.74 ±0.054, 0.26±0.24,0.48 ±0.033 mg/L and 23.45±1.18 u/L), (0.81±0.049, 0.30±0.024, 0.51±0.029 mg/dl and 26.20±1.38 u/L), (0.55 ± 0.039, 0.18 ± 0.17, 0.37 ± 0.026 mg/dl and 15.80 ± 1.54 u/L) when compared with the control group with P values (0.030, 0.036, 0.049 and 0.000), respectively.

Keywords: Viral hepatitis, liver biochemical test, Libyan’s patients.