DEVELOPMENT AND EVALUATION OF SOLID DISPERSION OF TADALAFIL BY FUSION AND SOLVENT EVAPORATION METHOD

Ikram*, Kapil Kumar and Deepak Teotia

ABSTRACT

Tadalafil, basically is a phosphor- diesterase-5, selective and potent inhibitor. It is recommended in erectile dysfunction. It is also used in arterial hypertension. It is having low aqueous solubility thus it shows poor bioavailability of about 28% by after oral administration. in current study an attempt was made to study Tadalafil SD formulations to enhance its solubility and dissolution, increase in solubility and thus improvement in its bioavailability. Two different methods were used to prepare SD formulations of Tadalafil, fusion method and solvent evaporation method. Preapred SD formulations were evaluated on different parameters. In the FTIR spectra Tadalafil+PVP K30 and Tadalafil+PEG 6000, there was not any significant change in the peaks, it indicates that the compatibility of Tadalafil with PVP K30 and PEG 6000. The bulk densities of the prepared granules was found to be in between 0.414±0.08 to 0.496±0.06. All SD formulations has shown good flow properties. Repose angle values were in between 21.28±0.08-29.66±0.09. SD formulations are capable to improve the solubility profile of Tadalafil. On basis different evaluation parameters, current study concludes, formulation of batch SD4 was the optimum formulation.

Keywords: Tadalafil, SD formulations, solvent evaporation method, fusion method, in-vitro release study.