INTERACTION STUDIES OF CATECHIN WITH HPV E6 AND E7 BY MOLECULAR DOCKING

Ardra Asokan*, M. Thangavel, S. Balaji and  Murugesh Easwaran

ABSTRACT

Cervical cancer remains one of the major gynaecological disorder worldwide and these cases tend to progress at an alarming rate every year. Saraca indica belonging to the family Caesalpiniaceae is a universal panacea to the Ayurveda medicine. The plant bark tend to possess anti-cancer, anti-menorrhagia, anti-oxytocic, anti-microbial activity and has extended uses in all traditional medicinal formulations. Catechin is a polyphenol antioxidant found to be present in the bark of the plant. This insilico study was performed to identify the interaction and binding pattern of catechin compound with antigenic E6 and E7 of Human Papilloma viral proteins.Catechin, structure obtained from the database was docked with E6 and E7 using the Glide module of Schrödinger. Glide score of -7.7 was obtained for E6 with catechin compared to E7 oncoprotein Glide score -5.5, suggesting a higher interaction with E6.This study concludes that catechin functionally interacts with E6 and E7 proteins and further studies may help to understand the binding pattern and in developing an efficient drug from the compound.

Keywords: Catechin, E6, E7, Saraca indica.