PHARMACEUTICAL SYNTHESIS OF PYRIMIDINE DERIVATIVES PROJECTING NEW PHARMACEUTICAL DRUG DESIGN, ALONG WITH ITS ANTIFUNGAL ACTIVITY INCLUDING TOXICITY STUDIES

S. Singh*, Dr. Shamim Ahmad and Dr. Shamsher Alam

ABSTRACT

Nitrogen containing heterocyclic compounds have received considerable attention due to their wide range of pharmacological activity. Pyrimidine and their derivatives are considered to be important for medicinal drugs. As pyrimidine is a basic nucleus in DNA & RNA, it has been found to be associated with diverse biological activities. Numerous reports have appeared in the literature that highlights chemistry and uses of pyrimidines, and their derivatives like Sulfadiazine, Sulfamerazine, and Sulfamethazine. A series of Pyrimidine derivatives were synthesized to evaluate their antimicrobial activity, their structure were characterized by UV, NMR, IR and Mass spectrometer. Among the tested Pyrimidine derivatives P-1 shows good activity against Penicillium chrysogenum and lesser toxicity.

Keywords: Antifungal activity, antibacterial activity, analgesic activity, Pyrimidine.