A PROSPECTIVE STUDY ON ADVERSE DRUG REACTIONS IN CHRONIC KIDNEY DISEASE PATIENTS WITH HYPERTENSION

*Dr. Basavanna P. L, Asna Ashraf, Chethana H. T. and Dr. Niranjan M. R.

ABSTRACT

Hypertension (HTN) is very frequent in patients with renal disease and its prevalence increases as chronic renal failure (CRF) progresses. The prevalence of HTN in renal patients depends fundamentally on the degree of the renal failure and the type of nephropathy, but varies also, as in essential HTN, with age, sex, and body mass index. Objectives: The main objective of the study was to assess the adverse drug reactions in kidney disease patients with hypertension. Materials and Methods: The study was carried at Nephrology department of K R Hospital, Mysore, Karnataka, from April 2020 to September 2020. A total of 84 patients were enrolled in the study as per the inclusion and exclusion criteria. Patient’s demographics data were collected using data collection forms. The adverse drug reactions were analyzed by using Naranjo causality assessment scale and Hartwig’s severity assessment scale. Results: Out of 84 candidates, females show dominance over males. 14 were presented with ADRs (16.7%). Hypokalemia, vomiting & headache and interstistial nephritis were the most commonly reported ADRs. 57.1% of ADRs were mild and 42.9% were moderate. 42.9% of ADRs were probable and 57.1% were in the possible category. Conclusion: The study was conducted to assess the adverse drug reactions found in hypertensive kidney patients. It can be reduced by pharmacist intervention, providing education and awareness about the disease and importance of medication adherence among the study population.

Keywords: Adverse drug reaction (ADR), Chronic Kidney Disease (CKD), Hypertension (HTN) hypokalemia, interstistial nephritis.