EVALUATION OF GLOMERULAR FUNCTION IN WOMEN WITH PREECLAMPSIA.

Dr. Amit D. Sonagra.*, Dr. Asmabi Makandar, Dr. Shrikant Chandrakar, Dr. Juhi A. Sonagra and Dr. K. Dattatreya

ABSTRACT

Introduction: Preeclampsia is defined as elevation of BP ≥140/90 mm of Hg after 20 weeks of gestation and proteinuria of ≥300mg/24hours or ≥1+ by dipstick method in a random urine sample. Preeclampsia causes widespread endothelial dysfunction leading to hypertension. It is associated with high occurrence of damage to kidney glomeruli. Damage to kidney may lead to elevated serum creatinine levels & reduced Glomerular Filtration Rate (GFR) which can be used for evaluation of glomerular function. Objectives: To compare and to evaluate role of serum creatinine level & GFR among women with preeclampsia & normal pregnancy. Materials and methods: Case control study was done taking 35 women with preeclampsia as cases and 35 women with normal pregnancy as controls. Serum creatinine was measured using Jaffe’s Kinetic method. GFR was calculated using Cockcroft-Gault formula & MDRD formula. Statistical analysis was done using SPSS 17.0. Results: Serum creatinine was significantly increased in cases when compared with controls (p<0.001). GFR was significantly low in cases when compared with controls (p<0.001). Conclusions: Presence of glomerular damage leads to elevated serum creatinine & reduced GFR. GFR gradually decreases as the disease severity increases. Regular monitoring of GFR in women with preeclampsia may give a clue of associated kidney damage.

Keywords: Cockcroft-Gault formula, glomerular filtratition rate, MDRD formula, preeclampsia, serum creatinine.