PREVALENCE OF SOME ENTEROVIRUSES ANTIBODIES AMONG NEONATES OF TAIF GOVERNORATE, SAUDI ARABIA DURING 2018

Afnan Al-ghuraybi*, Lamia Ahmed and Khalid Abo Khosheim

ABSTRACT

Objective: Investigate the prevalence of Coxsackievirus and Echovirus antibodies among neonates screened for thyroid stimulating hormone (TSH) of Taif Governorate. Methods: A total of 80 cord blood samples were included in this study for screening of thyroid stimulating hormone (TSH), Coxsackievirus and Echovirus antibodies by using ELISA test in neonates of Taif Governorate during the period from January 2018 till May 2018. Samples were classified according to TSH antibodies level into two main groups; diseased group (high TSH) and control group (normal TSH). Results: In the control group, of 40 cases, 10 (25%) samples were positive for coxsackievirus IgG and only 3 (8%) samples were positive for coxsackievirus IgM but without any evidence of clinical infection. All samples of the control group were negative for either echovirus IgG or IgM. In the diseased group, of 40 cases, only 10 (25%) samples were positive for coxsackievirus IgM but without any evidence of clinical infection and no samples were positive for coxsackievirus IgG. All samples of the diseased group were negative for either echovirus IgG or IgM. The study revealed a significant correlation between TSH status and coxsackievirus exposure. Conclusion: This study declared that no antibodies had been detected for either Echovirus IgM or Echovirus IgG. The prevalence of Coxsackievirus (12.5% for Cox IgG and 16.25% for Cox IgM) is very low among children neonates of Taif governorate when compared to the global prevalence rate.

Keywords: Coxsackievirus, Echovirus, Prevalence, ELISA, Taif.