EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

CLINICAL PROFILE OF FALCIPARUM MALARIA IN HOSPITALIZED CHILDREN

Dr. Md Jamshed Alam*, Dr. Habiba Jesmin, Dr. Most Monira Begum, Dr. Noor Uddin Talukder, Dr. Nazmul Hossain, Dr. Saiful Islam and Dr. Fakhrul Amin Badal

ABSTRACT

Background: Malaria; a global health problem which affects more than 40% of the world population in 143 countries. Over 300 millions of new malaria cases are added every year. It kills more than one million people worldwide each year and of these more than 15-25% are under 5 children. In South East Asia 9 countries out of 11 including Bangladesh are facing malarial health problem seriously. Main victims of this problem are children and pregnant women. They are 75% of total affected people. Objective: In this study our main goal is to see the variable clinical presentations of falciparum malaria in children and response to therapy. Methods: Total 100 cases of falciparum malaria, in the age group of 9 months to 12 years, were studied in the paediatric ward of Chittagong Medical College Hospital from March to August, 2003 with the objectives of studying the clinical presentations of falciparum malaria and their response to therapy, in children. Result: Majority of patients 63% had parasite count 500-10,000 their peripheral blood and count was plenty in only 2% cases. Most of the patients were anaemic but 13% cases had sever anaemia. Leucoopenia was observed in 5% leucocytosis in 39% cases. Evidence of haemolysis was present in 22% cases; which included jaundice, severe anaemia (Hb%=<5 g/ dl), increased serum bilirubin level and reticulocytosis. CSF study was done in 10 cases of cerebral malaria. CSF pressure was found to be raised in 3 cases, other laboratory findings of CSF were normal. Conclusion: Only Plasmodium falciparum causes severe malaria. Children are most vulnerable to this. Hill-tracts being forest area, Chittaagong, Cox’s bazaar being foot- hill areas are endemic zone for falciparum malaria. So this health problem is a headache of this region. Which needs evaluation and further re-evaluation of malaria situation time to time.

Keywords: Plasmodium falciparum, falciparum malaria, leucoopenia, haemolysis.

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