HISTOPATHOLOGICAL STUDY OF PROSTATE LESIONS-AN INSTITUTIONAL EXPERIENCE

Dr. Neha Mahajan*, Dr. Vaishali Nagose, Shirish Gondane and Dr. Vipin Todase

ABSTRACT

Introduction: Prostate gland pathologies are an important cause of morbidity and mortality in male patients. Disease spectrum for prostate comprises of inflammatory conditions, benign hyperplasia, malignancies, etc. Prostatic biopsy is an important test which helps determine various benign conditions as well as cancers in patients with specific indications. Other diagnostic modalities like radiology, prostatic biomarkers have developed, however histopathological examination on tissue biopsy is the gold standard for final diagnosis. Aims and objectives: To study Histopathological features in transurethral resection of prostate (TURP)and needle biopsies and to classify tumours of prostate as per WHO recommendations with analsysis of adenocarcinoma prostate according to Gleason`s grading system. Materials and methods: This study is a prospective study which was conducted from January 2018 to December 2019.The biopsies were fixed in 10% neutral buffered formalin and routine paraffin processing followed by hematoxylin and eosin staining was done. All the specimens were analysed with reference to type of specimen, age of patient and histopathological diagnosis. Results and conclusions: Benign hyperthrophy of prostate (BHP) was the commonest encountered lesion 114 cases (85%) which was accompanied by prostatitis in many cases. Prostatic adenocarcinoma was found in 10 cases(7.4%).Gleason`s score were predominantly of high values 7-9.The age range was 25 to 89 years and mean age was 57 years.

Keywords: Prostate, Lesions, Histopathology, Gleason score.