PRIMARY INTRAOCULAR LYMPHOMA

Dr. Mohmad Uzair(M.S)*, Dr. Amit Mehtani(M.S, DNB), Dr. Deepak Varma(DOMS) and Dr. Jatinder Singh Bhalla(MS, DNB)

ABSTRACT

Primary intraocular lymphoma (PIOL) is an ocular malignancy that is a subset of primary central nervous system lymphoma (PCNSL). Although rare, the incidence has been rising in both immunocompromised and immunocompetent populations. The majority of PIOL is diffuse large B-cell lymphoma, though rare T-cell variants are described. Diagnosis remains challenging for ophthalmologists and pathologists. PIOL can masquerade as noninfectious or infectious uveitis, white dot syndromes, or occasionally as other neoplasms such as metastatic cancers. Laboratory diagnosis by cytology has been much aided by the use of immunocytochemistry, flow cytometry, biochemical finding of interleukin changes (IL10:IL6 ratio>1) and cellular microdissection with polymerase chain reaction amplification for clonality. Use of several tests improves the diagnostic yield. This article is aimed at providing recent advances in diagnosing and management of PIOL.

Keywords: microdissection, clonality, immunocompromised and immunocompetent.