PARAMETERS OF HUMORAL IMMUNITY IN WOMEN OF REPRODUCTIVE AGE WITH UTERINE MYOMA

Isanbaeva L. M., *Musakhodjaeva D. A. and Eshimbetova G. Z.

ABSTRACT

Background. Key factors in the pathogenesis of uterine myoma are - stimulation of proliferation, impaired apoptosis processes in myometrics and the appearance of various growth factors. The immune system plays a significant role in maintaining tissue homeostasis in the body. Any processes associated with the enhancement of cell proliferation processes are accompanied by immune disorders and initially the disorders themselves in the immune system can lead to the initiation and growth of tumors. Рurpose of the study. Study of some parameters of immunity in women of reproductive age with different growth rates of uterine fibroids. Materials and Methods. Studied parameters of humoral immunity and indicators of non-specific protection factors in 123 women of reproductive age, of which 65 patients had simple uterine myoma (1 group) and 58 patients had fast-growing uterine myoma (2 group). The control group consisted of 30 women of reproductive age without uterine fibroids. Results. An analysis of the results of the studies carried out indicates changes in all parts of the immune system. It was revealed that with uterine myoma, the level of the total pool of B-lymphocytes and an imbalance in the synthesis of immunoglobulins are increased. With a rapidly growing uterine myoma, the level of IgG and IgA is increased, and the synthesis of IgM and the level of killer cells is reduced. Apparently, these changes can be considered markers of the rapid growth of uterine fibroids.

Keywords: uterine myoma, clinical course, the immune system, humoral link of immunity, factors of nonspecephical protection.