DESIGN AND DEVELOPMENT OF PRONIOSOMAL FILM FORMING GEL OF CRAMP BARK EXTRACT

Sofiya R. Moris*, Mohini Baile, Dr. Ashish Jain and Shubhangi Kshirsagar

ABSTRACT

The aim of present work was to develop, characterize, and optimize the proniosomal film forming gel containing Cramp bark herbal extract for menstrual pain. The effect of span 20 and span 80 on penetration of proniosomal gel. Four formulations are prepared by using span, lecithin and cholesterol. Proniosomal gels was prepared and evaluated for physicochemical parameters like pH, viscosity, spreadability, etc. have been studied. Invitro diffusion studies using Franz diffusion cell. The pH of the gel is maintained in the range of 6.8 -7 by using triethanolamine to prevent itching and irritation of the skin. Out of four formulations the optimized formulation was selected by entrapment efficiency and diffusion studies. FTIR studies showed compatibility between polymer and extract. From the present studies it is concluded that the film forming gel would help to increase the residence time as well as help in enhancing the permeation of the cramp bark extract and provide around the clock relief from Dysmenorrheoa.

Keywords: Cramp bark, proniosomal gel, Dysmenorrhea, Menstrual pain.