A REVIEW ON CONCEPTUAL OVERVIEW ON DEVELOPMENT AND CHARACTERIZATION OF SUPERPOROUS HYDROGELS A PROMISING TOOL FOR GRDDS

*Nitla Sirisha, D. Vinay Kumar, K. Srinivas Reddy and K. Lowkya

ABSTRACT

In the pharmaceutical field one of the convenient approach in oral drug delivery system to attain desired therapeutic action is done by prolonged release and desired drug delivery in GIT as most of the drugs posses short gastric retention time which eliminates the drug quickly from the stomach this will not produce desired therapeutic action, in order to overcome this, Gastroretentive dosage forms are developed which prevents the gastric emptying of the drug immediately after its administration. So as to overcome this Superporous hydrogels are developed. Superporous hydrogels are generally developed as novel drug delivery systems for those drugs whose absorption window is in stomach and upper part of GIT These systems should immediately swell in stomach and maintain their integrity in the harsh stomach environment. The water absorption by SPHs was done by capillary action not diffusion. Second generation SPH composites and third generation SPH hybrids were developed to achieve good mechanical strength as SPHs are having poor mechanical strength. The synthetic features and properties were being developed from years in order to maintain its integrity in Gastrointestinal tract(GIT). This review discusses the formulation, advantages, disadvantages, methods of synthesis, various generations, drug loading techniques, drying of SPHs and characterization of SPHs.

Keywords: Superporous hydrogel, Gastric retention, Absorption window.