SYSTEMIC MASTOCYTOSIS WITH AN ASSOCIATED MYELOPROLIFERATIVE NEOPLASM: CASE REPORT

*Anis Mzabi, Maissa Thabet, Wiem Romdhane, Jihed Anoun, Fatma Ben Fredj and Chadia Laouani

ABSTRACT

Systemic mastocytosis is a rare disease. We describe a new case of systemic mastocytosis with an associated hematologic neoplasm. A 36-year-old woman hospitalized for exploration of febrile asthenia and bone pain. The chest X-ray showed a heterogeneous appearance of the sternum with mixed osteocondensing and osteolytic process. The bone scintigraphy revealed several foci of hyperfixation in the sternum, humerus, femurs and pelvis. The myelogram as well as the bone marrow biopsy revealed rounded cells with a central nucleus and a finely granular, eosinophilic cytoplasm. This form of systemic mastocytosis with an associated hematologic neoplasm is rarely reported.

Keywords: Systemic mastocytosis, myeloproliferative neoplasm.