FORMULATION AND EVALUATION OF LINEZOLID FILM COATED TABLETS

Surbhi Sirswal* and Aman Mittal

ABSTRACT

The present investigation is undertaken with an aim to formulate and evaluate Film coated tablet of linezolid. The drug powders were subjected for preformulation studies. The Preformulation characteristics are within the Pharmacopoeial specifications. The drugs and excipients compatibility were carried out by FT-IR studies. The spectra showed that there was no interaction between them. The dissolution profile were carried out in Dissolution apparatus and then in UV spectrophotometer. For Linezolid-600 mg tablets, the main purpose of this study is to improve the hardness and dissolution profile of the core tablet and to minimize the defects occurs during coating of tablet. Optimization was done and it was found that dissolution release profile and hardness were found to be best and after coating, the tablet was found without any coating defect by non-aqueous coating i.e. IPA. Film coating of TiO2 and IPA coating of 2 %w/w was done on Linezolid tablets as to avoid spores which occurs during the aqueous coating. Five formulations were prepared by the name of SAD01-SAD-05. For coating, two different types of coating material were used (aqueous coating and non-aqueous coating). The granules were evaluated for angle of repose, bulk density, compressibility index and drug content etc. The tablets were also subjected for thickness, hardness, friability and in vitro release studies. Evaluation parameters like weight variation, hardness, thickness, friability and disintegration test were performed. Results found that release profile of batch no. SAD-05 shows better hardness and dissolution profile of core tablet and good coating appearance after non-aqueous coating. This formulation is taken as an ideal or optimized formulation.

Keywords: Linezolid; Preformulation; Film Coating; Hardness; Dissolution study etc.