EFFICACY OF LYCOPENE CAPSULES IN ORAL SUBMUCOUS FIBROSIS

Dr. Nitin Kole, Dr. Mithare Sangmesh, Dr. Paramita Ingle, Dr. Meenal Jethlia, Dr. Pratik Parkarwar, Dr. Rajendra Birangane

ABSTRACT

Oral sub mucous fibrosis is the premalignant condition affecting the oral cavity and most prevailing in youthful generation. The etiology of this condition is consumption of betel nut causing reduce mouth opening, burning sensation and finally the fibrosis of mucosa. The subjects have the symptoms like stiffness of oral mucosa, difficulty in swallowing, alter speech, shrunken uvula. So this condition can be prevented and controlled by stoppage of compution of betel nut, topical and systemic medicines, mouth opening exercises and surgery. In the medicines antioxidant, corticosteroids (topical), turmeric, immused milk, vasodilators are used and found to be effective. The study was undertaken on 50 subjects suffering from Grade I and Grade II OSMF with fifteen days interval and prescribed on Lycopene and placebo for three months. There was significant improvement in burning sensation and mouth opening of OSMF subjects. The study concluded that the administration of Lycopene capsules showed improvement in mouth opening and decrease in the burning sensation in the oral cavity.

Keywords: Oral Submuocus Fibrosis, Premalignant condition, Lycopene Capsules, Stiffness, Burning, Trismus, Betel nut.