EFFECT OF HEMODIALYSIS ON CONCENTRATION OF TOTAL PROSTATE SPECIFIC ANTIGEN AMONG PATIENTS WITH CHRONIC RENAL FAILURE ATTENDING BRACK GENERAL HOSPITAL AL-SHATI, LIBYA

Ali, F. Hawad, Abdullah Shebah*, Eljelani Salim, A.A. Elwafa, Abdulbasit Naiel, Maryam M. Bisher, Nabiha Aljoaad, Albashir M. A. Yhmed, Mohamed Farag Elbreki and Hamzah Saad

ABSTRACT

Hemodialysis is the most common method used for renal replacement therapy for patients with kidney disease. Tumor markers (TMs) are widely used for the follow-up of progression and response to treatment of certain neoplastic diseases, but their specificity in hemodialysis patients is controversial. Prostate-specific antigen (PSA) has been shown to be a useful marker in the early detection of prostate cancer. Objective: this study were aimed to determine the total prostate–specific antigen (t–PSA) levels in hemodialysis patients in comparison to normal subjects, as well as the influence of the dialysis duration on its levels. Materials and Methods: This study was conducted on 44 persones, from which 22 hemodialysis patients suffering from Renal Failure and 22 persones seemingly healthy people, they were used as control samples. Results: t-PSA in hemodialysis patients had higher t-PSA levels compared with the healthy subjects (0.8 ±0.80 vs.0. 6 ±0.33 ng/ml, p ˃ 0.05), although this difference was not statistically significant. Concentration of t-PSA was varied among patient groups according to their dialysis periods, hence t-PSA levels were decreased as dialysis period increased. However, this variation was not statistically significant (p ˃ 0.05). Conclusion: In this present study, the increased levels of t-PSA concentration were recorded among both hemodialysis patients and Dialysis patients who have fewer years of dialysis, however, statistical analysis has shown no significance. as the P-value was (p ˃ 0.05).

Keywords: Prostate-specific antigen, Renal failure, Hemodialysis, TMs, Dialysis periods.