ESTIMATION OF DOMPERIDONE AND PANTOPRAZOLE SODIUM BY AREA UNDER CURVE METHOD

Jyotsna R. Chopade* and Sonali Khalate

ABSTRACT

Background: A simple, accurate, rapid and precise spectrophotometric method has been developed for simultaneous estimation of Pantoprazole and Domperidone in pharmaceutical dosage form. Method: This method was based on UV spectrophotometric determination of two drugs, using Area under Curve method. It involves measurement of area under curve in the range of 268-278 nm (For Pantoprazole) and 276-290 nm (For Domperidone) for the analysis in methanol. Result: The linearity was observed in the concentration range of 2-12 μg/ml for Lafutidine and 3-18 μg/ml for Domperidone. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of Lafutidine and Domperidone in bulk, and combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.

Keywords: Domperidone and Pantoprazole sodium, Ultraviolet spectrophotometry, Area Under Curve method.