A REVIEW OF STEM CELL THERAPY FOR MANAGEMENT OF PARKINSON’S DISEASE

S. P. Senthil*, T. Indhumathi, M. Sakthivel and R. Senthamarai

ABSTRACT

Parkinson’s disease (PD) is a common neurodegeneration disorder. While a number of non-motor manifestations arise, the typical clinical features involve a movement disorder consisting of bradykinesia, resting tremor, and rigidity, with postural instability occurring at a later stage. There is no disease modifying treatments, and management is centered on symptom control using primarily dopaminergic drugs. While effective at improving the motor symptoms of PD, these treatments result in significant adverse effects, due to non targeted and non physiological delivery of dopamine to the brain. In this review we will discuss the how to reconstruct nigro-striatal neuronal pathways using dopaminergic neurons and targeting by cell based therapy to overcome adverse effects of traditional treatment.

Keywords: Parkinson’s disease, stem cell, cell based therapy, regeneration therapy.