REVIEW ON APPROACHES TO DEVELOP ORODISPERSIBLE TABLETS(ODT’S)

Divya R.*, Dr. Gururaj S. Kulkarni and Dr. Padmaa M. Paarakh

ABSTRACT

Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. This is also called as orodispersible, mouth dissolving, rapidly disintegrating, and fast melt system. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for paediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Conventional preparation methods are spray drying, freeze drying, direct compression, Moulding, and sublimation etc, while new technologies also have been developed for the production of orodispersible tablets. This review depicts conventional, recent and patented technologies that are used to prepare orodispersible tablets in detail.

Keywords: Orodispersible tablets, Approaches, Superdisintegrants, Conventional techniques, Patented technologies.