OCULAR DRUG DELIVERY SYSTEM: A NOVEL APPROACHES

Sonali*, Mohd. Aqil Siddiqui, Amresh Gupta, Arpita Singh, Swarnima Pandey and Nitish Kumar

ABSTRACT

This technique has been a major challenge for scientists due to its unique anatomy and physiology which contains various types of barriers such as different layers of cornea, sclera, retina including the blood-aqueous and blood–retinal barriers, choroidal and conjunctival blood flow, etc. To overcome these problems various types of dosage forms such as nanoparticles, nano micelles, liposomes, and micro-emulsions have been developed. Also, therapeutic drug levels are not maintained for a longer duration in target tissues. Last few decades, ocular drug delivery research accelerated advanced towards developing novel, safe, and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. There are many eye ailments that affected the eye and one can lose eyesight also. Therefore, many ophthalmic drug delivery systems are available. It divided into two types one is conventional and another is non-conventional drug delivery systems. Generally, available ophthalmic preparations are eye drops and ointments about 70% of the eye dosage formulations in the market.

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