DEVELOPMENT AND CHARECTERIZATION OF GLIBENCLAMIDE LIPOSOMAL FORMULATION

Ranjeetha A. R.*, Vazir Ashfaq Ahmed, Swathi K., Rashmitha N. M., Priyanka Raj G. and Monisha M. N.

ABSTRACT

The aim of the present investigation was to design a liposomes containing glibenclamide. Liposomes were prepared by the thin film hydration method by using chloroform as a solvent. Liposomes containing glibenclamide formulations were prepared by different concentration of lecithin and cholesterol by thin film technique. these formulations were evaluated for entrapment efficiency , zeta potential ,surface morphology and in vitro drug release. Coating of liposomes resulted increases the zeta potential. highest entrapment efficiency was observed in F1and F3 92%and 94%. The percent drug release from F1-F4 and CF1 was observed as follows F1-88.57%, F2-73.31%, F3-76.29%,F4-90.97%, and F1 coated as a CF1-69.85%. release kinetics folows the higuchi plot and non –fickian diffusion mechanism.

Keywords: Glibenclamide, liposomes, thin film hydration method, invitro – diffusion.