ESTIMATION OF SERUM ?2 MICROGLOBULIN IN ORAL CANCER AND POTENTIALLY MALIGNANT LESIONS OF ORAL CAVITY BY CHEMILUMINESCENCE IMMUNE ASSAY

Dr. Daya K. Jangam*, Dr. Sana Fatema, Dr. Priyanka Kale, Dr. Ashwini Desai

ABSTRACT

Introduction: Oral cancer is highly prevalent in Indian population. It accounts for approximately 30-40% of all cancers in India, tumor markers have been introduced for screening purpose, diagnosis, prognosis. Aim: To find out the correlation of the serum level of β2 microglobulin in patients with oral cancer and potentially malignant lesions of oral cavity and to evaluate its potential as a biomarker in early detection and prognosis. Materialsand methods: It was a case control study. The study comprised of three group of 60 subjects.Group I consisted of 20 subjects with clinically and histopathologicallydiagnosed cases of Oral cancer. Group II consisted of 20 subjects withoral potentially malignant lesion (PML) cases and group III consisted of control group with 20 healthy subjects without any deleterious habits. “Serum β2 microglobulin” was estimated using chemical luminiscenceimmuno assay kit. Biochemical parameter was compared between study group and control group. Results: There was increase in level of serum β2 microglobulin from stage I: 2072.5±316.0(ng/mL) to stage IV (3624.5±1591.7ng/ml.) of oral cancer and average serum β2 microglobulin level differed significantly between stage I and stage IV in oral cancer group. (p<0.05). Also the average serum β2 microglobulindiffered significantly across Moderately Differentiated and Well Differentiated groups (P-value<0.05). Conclusion: Study revealed that serum β2 microglobulinwas seen increased in oral cancer and a positive correlation of serum β2 microglobulin with the disease progression was noted. Therefore Serum β2 microglobulin can be used as a prognosticmarker for oral cancer.

Keywords: biomarker, chemiluminiscenceimmunoassay, oral cancer, potential malignant lesions, serum ?2 microglobulin.