FORMULATION, EVALUATION, AND COMPARISON OF ANTI-DIABETIC BAGO LEAVES (GNETUM GNEMON LINN., FAMILY: GNETACEAE) TABLETS AGAINST COMMERCIALLY AVAILABLE METFORMIN HCL TABLET

Duran, Kitz Marc Anthony B., Luceno, Anthonette E., Mallabo, Wynze Andre P., Marin, *Anthony R., Pereyra, Laica Marie R., Regis, Ma. Carmela R.

ABSTRACT

Gnetum gnemon L. tree grows in tropical areas and is native to countries like in the Philippines. The main purpose of this study is to find new anti-glycemic drug by formulating the tablet dosage form of Bago leaves. In statistical results, sample tablets was compared and evaluated with Metformin tabets. During the tests, weight variation (4.60%), friability (0.60), hardness (4.30), and disintegration tests (7.50) of Bago tablets got a good result. The value of each tests for sample tablets are near with the market available anti-diabetic tablet of Metformin except from its color (yellow to brownish white). Bago tablets shown promising effects that can lead to produce a good or better product than available anti-diabetic drugs. In conclusion, the Bago tablets derived from Gnetum gnemon L. can be a substitute drug for Metformin tablets which act as anti-glycemic drug in patients with diabetes mellitus.

Keywords: Bago leaves effect in diabetes, Metformin HCl, Anti-diabetic tablet of Gnetum gnemon, Treatment for type II diabetes, Use of Gnetum gnemon L in diabetic patient.