SYNTHESIS AND ANTIBACTERIAL INVESTIGATION OF SOME AMIDES

*Unuigbe Osaherunmwen Isonah Pharm D and Emmanuel Eimiomodebheki Odion PhD

ABSTRACT

The purpose of this work was to synthesize amide derivatives with possible antibacterial activities. The method involves the reaction of amines with pamitoyl chloride in the presence of trimethylamine. The products were purified using chromatographic techniques and were characterized using Fourier Transform Infra-Red Spectrophotometry (FT-IR), Nuclear Magnetic Resonance (1HNMR, 13CNMR), Mass Spectroscopy (MS) and Elemental Analyses. Agar diffusion technique was used to screen for the antibacterial activity, by dabbing the Mueller–Hinton agar plates with bacteria suspension and subsequently applying of 1000 μg/ml of the synthesized compounds. It was observed that as the bulkiness of the aromatic group increases, the melting point also increases. The antibacterial screening results show no zone of inhibition suggesting that none of the synthesized compound has antibacterial property against the tested strain.

Keywords: Propargylamine, Benzylamine, 1-Naphthyl methylamine, Pamitoyl chloride, Triethylamine.