GENE THERAPY: A RECENT ADVANCES IN COVID – 19

Amand Alekhya* and Dr. G. Uma Rani

ABSTRACT

As gene therapy is one of the blistering themes of the latest century, it carries the enthusiasm of a cure to most of diseases, the dispute surrounding the altering of human defects, and the promise of a type of medical therapy most of us would never imagine possible. Gene therapy became feasible through the implementation of genetics and bioengineering that permit exploit vectors for delivery of extrachromosomal material to target cells. Safe techniques have been fabricated to do this, by means of several viral and non –viral vectors. Coronavirus disease(COVID-1 9) is a particular infectious respiratory disease caused by a newly discovered coronavirus, SARS-CoV-2.There are several challenges associated with the treatment of the COVID-19 during the contemporary outbreak. The virus is the positive strand RNA one with high homology to bat coronavirus. The pathogenic mechanism of the new coronavirus is still unclear, which is a significant obstacle to the development of drugs and patients rescue. The broadcasting and epidemic of the novel coronavirus highlighted the urgent need for new therapeutic technologies. Molecular biology tools that include gene editing approaches such as CRISPR-Cas12/13-based SHERLOCK, DETECTR,CARVER and PAC-MAN, antisence oligonucleotides, antisence peptide nucleic acids, ribozymes, aptamers and RNAi silencing approaches fabricated with cutting edge scientific advances equated to conventional diagnostic or treatment methods could be vital in COVID-19 and other future outbreaks. Thus in this review, we will explore potent of molecular biology approaches that can transfigure treatment of viral infections and therapies to fight COVID-19 in a highly specific, stable and efficient way.

Keywords: Gene therapy, vectors, SARS-CoV-2, Novel CRISPR approaches.