SCREENING OF SOLVENT EXTRACT OF PSIDIUM CATTLEIANUM LEAVES FOR ANTICANCER ACTIVITY AGAINST HEPATIC CANCER CELL LINE

Anusree K. V.* and Dhivya R.

ABSTRACT

Plants are used for medical functions since the start of human history and are the basis of modern medicine. From the dawn of ancient drugs, chemical compounds derived from plants are accustomed to treat human diseases. Natural sources have received increasing attention over the past 30 years for their potential as novel cancer preventive and therapeutic agents. In this view the present study was carried out to investigate the anticancer property of acetone extract from Psidium cattleianum leaves against Chang liver cell line by MTT assay, antioxidant activity by DPPH assay and phytochemical analysis was investigated by standard protocols. Results revealed that ethanol extract of P. cattleianum exhibited maximum anticancer activity against Chang liver cell line. A rapid evaluation for antioxidants using DPPH assay demonstrated that leaf extract had excellent free radical scavenging capacity. The phytochemical screening showed the presence of alkaloids, flavonoids, glycosides, phenolic compounds, saponins, tannins and quinones.

Keywords: Anticancer activity; Antioxidant activity; DPPH Assay; Hepatic cancer cell line; MTT assay; Phytochemicals; Psidium; Solvent extracts.